DDI.AHRI.CMV.2022.v2 Africa Health Research Institute <_value> NADA Congenital and postnatal CMV infection in the era of WHO PMTCT Option B+ in rural South Africa AHRI.CMV.2022.v2 Prof Deenan Pillay Suresh B. Boppana Karen Fowler Prakash Jeena Benn Sartorius Nigel Klein Olivier Koole

Osee Behuhuma

Anita Edwards

Theresa Smit

Africa Health Research Institute NADA National Institutes of Health, USA 1R21HD083011-01 V2.0.0 1.4 Congenital CMV infection, postnatal CMV infection, HIV exposed infants MeSH subject headings Clinical; congenital CMV (cCMV) South Africa Demographic surveillance area of the Africa Health Research Institute; KwaZulu-Natal, uMkhanyakude district. The type of data included in the file (The following data sources used): Chart records (mother medical chart, infant medical chart for health histort and health card for anthropometry). Interviews. Biological/laboratory tests; and Clinical tests - audiometry (tympanometry followed by Otoaccoustic Emissions (OAE) testing for screening, infants with failed OAE will be referred for diagnostic testing - Auditory evoked Brainstem Responses (ABR) at Albert Luthuli Central Hospital. This study draws on quantitative data sources. Most exposure and all outcome data will be measured using objective instruments. AHRI.CMV.2022.v2 2872 329 Auto number CMV study 2872 1 2963 1513.182 849.147 Event Name 2872 Site 2636 236 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Do you agree for your sample to be stored for future research ? 777 2095 No 1 Yes Sysmiss Date/time (signed informed consent) 2665 2016-12-06 2018-12-11 Mothers Date of birth 2636 1970-03-03 2007-07-25 Age of mother (years) 2636 236 10 46 25.525 6.235 Highest level of education 2633 239 1 Never schooled 2 Attended Primary School 3 Attended High School 4 Matriculated 5 Obtained a certificate 6 Obtained a Diploma / Degree Sysmiss Employment 2623 249 1 Unemployed 2 Part-time Employed 3 Full time Employed Sysmiss Number of rooms in household 2635 237 1 23 5.362 2.737 Number of people in household 2635 237 1 46 8.244 3.804 Number of people in the household earning a monthly salary 2633 239 45 2.151 2.003 Other children (15 years) in the household 2633 239 No 1 Yes Sysmiss Number of other children (< 15 years) in household 2403 469 87 3.449 2.501 Age of youngest child (years) 2391 481 Age of 2nd youngest child (years) 2059 813 1142 7.523 25.236 Age of 3rd youngest child (years) 1562 1310 Age of 4th youngest child (years) 1021 1851 Age of 5th youngest child (years) 617 2255 Age of 6th youngest child (years) 303 2569 Age of 7th youngest child (years) 145 2727 Age of 8th youngest child (years) 63 2809 Close contact with preschool children during pregnancy (choice=None) 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Work with childre 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Household contact 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Nappy changes) 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Nose-wiping) 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Feeding children) 2670 202 Unchecked 1 Checked Sysmiss Close contact with preschool children during pregnancy (choice=Other) 2670 202 Unchecked 1 Checked Sysmiss Use of cigarettes / tobacco 2628 244 No 1 Yes Sysmiss Number of packs per day 9 2863 Number of years 9 2863 Use of alcohol 2615 257 No 1 Yes Sysmiss Number of drinks per week 44 2828 Febrile illness during current pregnancy? 2633 239 No 1 Yes 3 Unknown Sysmiss Hypertension 2631 241 No 1 Yes 3 Unknown Sysmiss Diabetes 2633 239 No 1 Yes 3 Unknown Sysmiss Tuberculosis 2630 242 No 1 Yes 3 Unknown Sysmiss Other 2595 277 No 1 Yes 3 Unknown Sysmiss Complications during current pregnancy 2519 353 No 1 Yes 3 Unknown Sysmiss HIV status 2636 236 1 Negative 2 Positive 3 Not tested/unknown Sysmiss On ART 1105 1767 1 Unknown 2 No 3 Yes Sysmiss Started ART during pregnancy 1077 1795 1 Unknown 2 No 3 Yes Sysmiss Year started ART 1101 1771 2001 2001 2002 2002 2003 2003 2004 2004 2005 2005 2006 2006 2007 2007 2008 2008 2009 2009 2010 2010 2011 2011 2012 2012 2013 2013 2014 2014 2015 2015 2016 2016 2017 2017 2018 2018 9999 Unknown Sysmiss Month started ART 1100 1772 1 January 2 February 3 March 4 April 5 May 6 June 7 July 8 August 9 September 10 October 11 November 12 December 13 Unknown Sysmiss Current ART regimen 1100 1772 1 FDC (TDF+3TC(FTC)+EFV) 2 Other Sysmiss Changed ART regimen since start ART 1100 1772 1 Unknown 2 No 3 Yes Sysmiss Date/time delivery 2636 2016-12-04 2018-12-10 Gravity 2635 237 Parity 2635 237 Gestation (weeks) 2596 276 4 44 38.753 1.554 Type of pregnancy 2625 247 1 Single 2 Twins 3 Triplets Sysmiss Mode of delivery 2636 236 1 Caesarian section 2 Normal vaginal delivery at hospital 3 Normal vaginal delivery at home 4 Vaginal delivery with vacuum or forceps Sysmiss Complete? 2670 202 Incomplete 1 Unverified 2 Complete Sysmiss Site 2628 244 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Validation check 2872 Infant part of multiple pregnancy (two or more babies)? 2571 301 No 1 Yes Sysmiss First born 49 2823 No 1 Yes Sysmiss Second born 32 2840 No 1 Yes Sysmiss Third born 2872 No 1 Yes Sysmiss Birth Weight (kg) 2663 209 1.2 5 3.048 0.494 Birth Length (cm) 2660 212 33 59 49.273 2.42 Gender 2667 205 1 Male 2 Female Sysmiss APGAR score (/10) after 1 minute 2663 209 6 91 9.01 1.682 APGAR score (/10) after 5 minutes 2663 209 Head circumference (cm) 2660 212 10 52 34.798 1.741 Signs of congenital CMV infection (choice=None) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Small for gestational age) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Hepatomegaly) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Jaundice) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Petechiae / Purpura) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Seizures) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Cardiac murmur) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Cataracts) 2670 202 Unchecked 1 Checked Sysmiss Signs of congenital CMV infection (choice=Microcephaly) 2670 202 Unchecked 1 Checked Sysmiss Saliva specimen obtained? 2667 205 No 1 Yes Sysmiss Result CMV PCR Saliva 2667 205 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Complete? 2670 202 Incomplete 1 Unverified 2 Complete Sysmiss Site 59 2813 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Mothers Date of birth 59 1973-05-28 2018-03-24 Infants Date of birth 60 2016-12-14 2018-11-26 Date visit 63 2017-01-20 2019-04-03 Informed consent signed for congenital CMV study 60 2812 No 1 Yes Sysmiss Date (first) saliva specimen taken 57 2016-12-14 2019-03-06 Saliva PCR CMV result at birth 45 2827 Negative 1 Positive 99 Unknown Sysmiss Date (first) positive result received by research assistant Date contacted by research assistant Admitted after birth 55 2817 No 1 Yes Sysmiss Number of days admitted 3 2869 4 45 18.667 22.855 Reason for admission 3 2869 1 Baby was well but was admitted due to mum requiring admission 2 Baby was unwell, requiring admission, specify: Sysmiss Evidence of CMV disease 39 2833 None 1 Congenital CMV inclusion disease 2 CMV Pneumonitis 3 CMV Colitis 4 CMV Hepatitits 5 CMV Retinitis 6 CMV Encephalitis 7 Other, specify Sysmiss Weight (kg) 58 2814 2.7 20.1 6.494 3.215 Length/height (cm) 57 2815 44 85 58.974 9.374 Head circumference (cm) 57 2815 Abnormalities on clinical examination 48 2824 None 1 Fever 2 Pneumonia 3 Hepatitits 4 Encephalitis 5 Retinitis 7 Other, specify Sysmiss Management plan paediatrics 49 2823 No need for further appointment 1 Regular follow-up at Hlabisa Hospital 2 Referral for specialist care Sysmiss Screening OAE performed 57 2815 No 1 Yes Sysmiss Reason? 4 2868 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time Screening OAE 51 2017-01-20 2019-04-03 Result screening Quick TEOAE right 52 2820 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening Quick TEOAE left 52 2820 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 right 51 2821 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 left 51 2821 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Otoscopy performed 19 2853 No 1 Yes Sysmiss Reason? 5 2867 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time otosocpy 10 2017-01-20 2019-02-13 Results otosocopy right side 10 2862 Canal clear 1 Canal obstructed Sysmiss Results otoscopy left side 9 2863 Canal clear 1 Canal obstructed Sysmiss Tympanometry performed 19 2853 No 1 Yes Sysmiss Reason? 15 2857 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time tympanometry Results tympanometry right 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Results tympanometry left 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Diagnostic OAE performed 19 2853 No 1 Yes Sysmiss Reason? 6 2866 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time diagnostic OAE 10 2017-01-20 2019-01-16 Result diagnostic Quick TEOAE right 9 2863 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic Quick TEOAE left 9 2863 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 right 11 2861 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 left 10 2862 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Management plan audiology 56 2816 No need for further examinations/appointment 1 Management for acute treatable condition 2 Follow-up at Hlabisa Hospital for diagnostic audiology and management of condition 3 Follow-up at Hlabisa Hospital for other (non audiology) services 4 Referral for other services 5 Monitor at next CMV visit Sysmiss Code of the person performing the audiology 55 2817 Audiologist 1 Thandeka Jwara 2 Thabisile Nduli 3 Thulile Khumalo 4 Thabile Hlabisa Sysmiss Saliva specimen (repeat) obtained? 64 2808 No 1 Yes Sysmiss Result (repeat) saliva specimen 56 2816 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Urine sample obtained? 60 2812 No 1 Yes Sysmiss Result urine specimen 42 2830 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Was DBS taken at birth (only if applicable - HIV exposed babies)? 24 2848 No 1 Yes 3 Unknown Sysmiss Result DBS (PCR HIV) specimen at birth (if applicable) 15 2857 Negative 1 Positive 2 Unknown 3 Not applicable Sysmiss Next appointment date 54 2017-03-10 2019-06-26 Name interviewer 63 2809 1 Thandeka Jwara 3 Thulile Khumalo 4 Thabile Hlabisa 5 Siphiwe Vusi Mabika 6 Xolisile Ceasar Sysmiss Complete? 202 2670 Incomplete 1 Unverified 2 Complete Sysmiss Infants Date of birth 18 2017-01-08 2018-11-26 Reason for missed visit 17 2855 1 Transfer to other health facility 2 Loss to follow-up (no contact) 3 Parent/caretaker choose to withdraw from study 4 Death 8 Other Sysmiss Date of death known 1 2871 No 1 Yes Sysmiss Date of death 1 2017-02-04 2017-02-04 Year of death 2872 2017 2017 2018 2018 2019 2019 2020 2020 2021 2021 9999 Unknown Sysmiss Month of death 2872 1 January 2 February 3 March 4 April 5 May 6 June 7 July 8 August 9 September 10 October 11 November 12 December 99 Unknown Sysmiss Day of death 2872 1 1 2 2 3 3 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 13 14 14 15 15 16 16 17 17 18 18 19 19 20 20 21 21 22 22 23 23 24 24 25 25 26 26 27 27 28 28 29 29 30 30 31 31 99 Unknown Sysmiss Admitted in hospital (after birth) 4 2868 No 1 Yes Sysmiss PCR HIV result (for HIV exposed infants) 16 2856 Negative 1 Positive 2 Unknown 3 Not applicable (not HIV exposed) Sysmiss Source of info for missed visit 16 2856 1 Telephone contact 2 Clinic contact 5 Other Sysmiss Complete? 202 2670 Incomplete 1 Unverified 2 Complete Sysmiss Site 128 2744 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Mothers Date of birth 127 1973-02-11 2017-09-18 Infants Date of birth 129 2016-12-14 2018-10-28 Date visit 131 2017-01-27 2019-06-26 Type of study visit 121 2751 1 Enrollment visit 2 Regular follow-up visit 3 Unplanned visit Sysmiss Informed consent signed for congenital CMV study 2872 No 1 Yes Sysmiss Date (first) saliva specimen taken 96 2016-12-14 2019-05-15 Saliva PCR CMV result at birth 81 2791 Negative 1 Positive 99 Unknown Sysmiss Date (second/confirmatory) saliva specimen taken 14 2017-01-20 2019-02-13 Saliva PCR CMV result (second/confirmatory sample) 47 2825 Negative 1 Positive 99 Unknown Sysmiss Admitted after birth 2872 No 1 Yes Sysmiss Number of days admitted 2872 Reason for admission 2872 1 Baby was well but was admitted due to mum requiring admission 2 Baby was unwell, requiring admission, specify: Sysmiss Visit to hospital/clinic since birth 2872 No 1 Yes Sysmiss Evidence of CMV disease 2872 None 1 Congenital CMV inclusion disease 2 CMV Pneumonitis 3 CMV Colitis 4 CMV Hepatitits 5 CMV Retinitis 6 CMV Encephalitis 7 Other, specify Sysmiss Health problems since last visit 116 2756 No 1 Yes Sysmiss Visit to hospital/clinic 115 2757 No 1 Yes Sysmiss Evidence of CMV disease 90 2782 None 1 Congenital CMV inclusion disease 2 CMV Pneumonitis 3 CMV Colitis 4 CMV Hepatitits 5 CMV Retinitis 6 CMV Encephalitis 7 Other, specify Sysmiss Weight (kg) 126 2746 3.8 20.9 9.234 2.708 Length/height (cm) 126 2746 49 90 69.233 9.272 Head circumference (cm) 125 2747 19 83 45.858 6.758 Abnormalities on clinical examination 101 2771 None 1 Fever 2 Pneumonia 3 Hepatitits 4 Encephalitis 5 Retinitis 7 Other, specify Sysmiss Infants age (weeks) 127 2745 2 116 43.276 27.265 Starting to make cooing sounds 2872 No 1 Yes Sysmiss Starting to smile 2872 No 1 Yes Sysmiss Brief eye contact 2872 No 1 Yes Sysmiss Starting to follow with eyes 2872 No 1 Yes Sysmiss Eyes are moving together 2872 No 1 Yes Sysmiss Starting to control head 2872 No 1 Yes Sysmiss Moving limbs symmetrically 2872 No 1 Yes Sysmiss Cooing 2872 No 1 Yes Sysmiss Starting to babble 2872 No 1 Yes Sysmiss Social smiling 2872 No 1 Yes Sysmiss Prolonged eye contact 2872 No 1 Yes Sysmiss Reacts to loud sounds 2872 No 1 Yes Sysmiss Can follow/track objects with eyes 2872 No 1 Yes Sysmiss Can bring hands to mid line and to the mouth 2872 No 1 Yes Sysmiss Lifts knees 2872 No 1 Yes Sysmiss Grasps objects 2872 No 1 Yes Sysmiss Lifts head when lying prone 2872 No 1 Yes Sysmiss Conversational babble 8 2864 No 1 Yes Sysmiss Says a few words, like mama 8 2864 No 1 Yes Sysmiss Stranger anxiety 8 2864 No 1 Yes Sysmiss Waves bye bye 8 2864 No 1 Yes Sysmiss Can stand supported 8 2864 No 1 Yes Sysmiss Crawling 8 2864 No 1 Yes Sysmiss Grasps with finger and thumb 8 2864 No 1 Yes Sysmiss Pointing 8 2864 No 1 Yes Sysmiss Management plan paediatrics 96 2776 No need for further appointment 1 Regular follow-up at Hlabisa Hospital 2 Referral for specialist care Sysmiss Screening OAE performed 126 2746 No 1 Yes Sysmiss Reason? 18 2854 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time Screening OAE 101 2017-01-27 2019-06-26 Result screening Quick TEOAE right 106 2766 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening Quick TEOAE left 106 2766 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 right 105 2767 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 left 105 2767 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Otoscopy performed 21 2851 No 1 Yes Sysmiss Reason? 11 2861 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time otosocpy 6 2018-01-15 2018-12-12 Results otosocopy right side 7 2865 Canal clear 1 Canal obstructed Sysmiss Results otoscopy left side 7 2865 Canal clear 1 Canal obstructed Sysmiss Tympanometry performed 20 2852 No 1 Yes Sysmiss Reason? 18 2854 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time tympanometry Results tympanometry right 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Results tympanometry left 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Diagnostic OAE performed 19 2853 No 1 Yes Sysmiss Reason? 8 2864 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time diagnostic OAE 10 2017-07-24 2018-01-18 Result diagnostic Quick TEOAE right 10 2862 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic Quick TEOAE left 10 2862 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 right 10 2862 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 left 10 2862 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Management plan audiology 20 2852 No need for further examinations/appointment 1 Management for acute treatable condition 2 Follow-up at Hlabisa Hospital for diagnostic audiology and management of condition 3 Follow-up at Hlabisa Hospital for other (non audiology) services 4 Referral for other services 5 Monitor at next CMV visit Sysmiss Code of the person performing the audiology 117 2755 Audiologist 1 Thandeka Jwara 2 Thabisile Nduli 3 Thulile Khumalo 4 Thabile Hlabisa Sysmiss Saliva specimen obtained? 132 2740 No 1 Yes Sysmiss Result (follow-up) saliva specimen 115 2757 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Urine sample obtained? 99 2773 No 1 Yes Sysmiss Result urine specimen 39 2833 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Was a DBS taken at birth (only if applicable - HIV exposed babies)? 59 2813 No 1 Yes 3 Unknown Sysmiss Result DBS at birth 32 2840 Negative 1 Positive 2 Unknown 3 Not applicable Sysmiss Was a DBS taken at 10 weeks (only if applicable - HIV exposed babies)? 52 2820 No 1 Yes 3 Unknown Sysmiss Result DBS (PCR HIV) specimen 18 2854 Negative 1 Positive 2 Unknown 3 Not applicable Sysmiss Name interviewer 133 2739 1 Thandeka Jwara 3 Thulile Khumalo 4 Thabile Hlabisa 5 Siphiwe Vusi Mabika 6 Xolisile Ceasar Sysmiss Complete? 202 2670 Incomplete 1 Unverified 2 Complete Sysmiss Site 2872 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Study ID Mother 2872 Sysmiss Mothers Date of birth Employment 2872 1 Unemployed 2 Part-time Employed 3 Full time Employed Sysmiss Number of rooms in household 2872 Number of people in household 2872 Number of people in the household earning a monthly salary 2872 Other children (< 15 years) in the household 2872 No 1 Yes Sysmiss Number of other children (< 15 years) in household 2872 Age of youngest child (years) 2872 Age of 2nd youngest child (years) 2872 Age of 3rd youngest child (years) 2872 Age of 4th youngest child (years) 2872 Age of 5th youngest child (years) 2872 Age of 6th youngest child (years) 2872 Age of 7th youngest child (years) 2872 Age of 8th youngest child (years) 2872 Childcare being given to the infant 2872 1 At home, looked after by mother or guardian 2 Attends daycare with a daycare mother 3 Attends a creche 4 Other, specify Sysmiss Name interviewer 2872 1 Thandeka Jwara 3 Thulile Khumalo 4 Thabile Hlabisa 5 Siphiwe Vusi Mabika 6 Xolisile Ceasar Sysmiss Complete? 2872 Incomplete 1 Unverified 2 Complete Sysmiss Site 2872 1 Hlabisa Hospital 2 Somkhele Clinic Sysmiss Study Id mother 2872 Infant Study Number 2872 Date visit Infants Date of birth Type of study visit 2872 1 Enrollment visit 2 Regular follow-up visit 3 Unplanned visit Sysmiss Informed consent signed for postnatal CMV study 2872 No 1 Yes Sysmiss Admitted after birth 2872 No 1 Yes Sysmiss Number of days admitted 2872 Reason for admission 2872 1 Baby was well but was admitted due to mum requiring admission 2 Baby was unwell, requiring admission, specify: Sysmiss Visit to hospital/clinic since birth 2872 No 1 Yes Sysmiss Evidence of CMV disease 2872 None 1 Congenital CMV inclusion disease 2 CMV Pneumonitis 3 CMV Colitis 4 CMV Hepatitits 5 CMV Retinitis 6 CMV Encephalitis 7 Other, specify Sysmiss Health problems since last visit 2872 No 1 Yes Sysmiss Visit to hospital/clinic 2872 No 1 Yes Sysmiss Evidence of CMV disease 2872 None 1 Congenital CMV inclusion disease 2 CMV Pneumonitis 3 CMV Colitis 4 CMV Hepatitits 5 CMV Retinitis 6 CMV Encephalitis 7 Other, specify Sysmiss Infant feeding since last visit 2872 1 Exclusive breastmilk 2 Mixed feeding 3 Exclusive formula feeding 4 Solid foods Sysmiss Weight (kg) 2872 Length/height (cm) 2872 Head circumference (cm) 2872 Abnormalities on clinical examination 2872 None 1 Fever 2 Pneumonia 3 Hepatitits 4 Encephalitis 5 Retinitis 7 Other, specify Sysmiss Infants age 2872 Starting to make cooing sounds 2872 No 1 Yes Sysmiss Starting to smile 2872 No 1 Yes Sysmiss Brief eye contact 2872 No 1 Yes Sysmiss Starting to follow with eyes 2872 No 1 Yes Sysmiss Eyes are moving together 2872 No 1 Yes Sysmiss Starting to control head 2872 No 1 Yes Sysmiss Moving limbs symmetrically 2872 No 1 Yes Sysmiss Cooing 2872 No 1 Yes Sysmiss Starting to babble 2872 No 1 Yes Sysmiss Social smiling 2872 No 1 Yes Sysmiss Prolonged eye contact 2872 No 1 Yes Sysmiss Reacts to loud sounds 2872 No 1 Yes Sysmiss Can follow/track objects with eyes 2872 No 1 Yes Sysmiss Can bring hands to mid line and to the mouth 2872 No 1 Yes Sysmiss Lifts knees 2872 No 1 Yes Sysmiss Grasps objects 2872 No 1 Yes Sysmiss Lifts head when lying prone 2872 No 1 Yes Sysmiss Conversational babble 2872 No 1 Yes Sysmiss Says a few words, like mama 2872 No 1 Yes Sysmiss Stranger anxiety 2872 No 1 Yes Sysmiss Waves bye bye 2872 No 1 Yes Sysmiss Can stand supported 2872 No 1 Yes Sysmiss Crawling 2872 No 1 Yes Sysmiss Grasps with finger and thumb 2872 No 1 Yes Sysmiss Pointing 2872 No 1 Yes Sysmiss Management plan paediatrics 2872 No need for further appointment 1 Regular follow-up at Hlabisa Hospital 2 Referral for specialist care Sysmiss Screening OAE performed 2872 No 1 Yes Sysmiss Reason? 2872 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time Screening OAE Result screening Quick TEOAE right 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening Quick TEOAE left 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 right 2872 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result screening QDP55 left 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Otoscopy performed 2872 No 1 Yes Sysmiss Reason? 2872 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time otosocpy Results otosocopy right side 2872 Canal clear 1 Canal obstructed Sysmiss Results otoscopy left side 2872 Canal clear 1 Canal obstructed Sysmiss Tympanometry performed 2872 No 1 Yes Sysmiss Reason? 2872 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time tympanometry Results tympanometry right 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Results tympanometry left 2872 1 Type A 2 Type B 3 Type C 4 Type D 5 Type AD 6 Equipment malfunction Sysmiss Diagnostic OAE performed 2872 No 1 Yes Sysmiss Reason? 2872 1 Equipment malfunctioning 2 Uncooperative participant (mother or infant) 3 Other Sysmiss Date/time diagnostic OAE Result diagnostic Quick TEOAE right 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic Quick TEOAE left 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 right 2872 1 Pass 2 Fail 3 CNT 4 Noise 5 Equipment malfunction Sysmiss Result diagnostic QDP55 left 2872 1 Pass 2 Fail 3 Could not test (CNT) 4 Noise 5 Equipment malfunction Sysmiss Management plan audiology 2872 No need for further examinations/appointment 1 Management for acute treatable condition 2 Follow-up at Hlabisa Hospital for diagnostic audiology and management of condition 3 Follow-up at Hlabisa Hospital for other (non audiology) services 4 Referral for other services Sysmiss Code audiologist 2872 Audiologist 1 Thandeka Jwara 2 Thabisile Nduli 3 Thulile Khumalo 4 Thabile Hlabisa Sysmiss Saliva specimen obtained? 2872 No 1 Yes Sysmiss Specimen barcode (repeat) saliva specimen 2872 Result (repeat) saliva specimen 2872 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Urine specimen obtained? 2872 No 1 Yes Sysmiss Barcode (repeat) urine specimen 2872 Result (repeat) urine specimen 2872 Negative 1 Positive 3 Indeterminate 99 Unknown Sysmiss Result DBS (PCR HIV) specimen 2872 Negative 1 Positive 2 Unknown 3 Not applicable Sysmiss Name interviewer 2872 1 Thandeka Jwara 3 Thulile Khumalo 4 Thabile Hlabisa 5 Siphiwe Vusi Mabika 6 Xolisile Ceasar Sysmiss Complete? 2872 Incomplete 1 Unverified 2 Complete Sysmiss