EVOLVE-HBV (Evaluation of Vukuzazi LiVEr disease - Hepatitis B): A retrospective serosurvey of Hepatitis B Virus (HBV) infection, exposure, and vaccine-mediated immunity using archived samples from the Vukuzazi Study (2018-2020). AHRI.EVOLVE.HBV Nompumelelo Mkwanazi Africa Health Research Institute Nesstar Publisher EVOLVE-HBV (Evaluation of Vukuzazi LiVEr disease - Hepatitis B): A retrospective serosurvey of Hepatitis B Virus (HBV) infection, exposure, and vaccine-mediated immunity using archived samples from the Vukuzazi Study (2018-2020). AHRI.EVOLVE.HBV Siyabonga Nxumalo Lusanda Mazibuko Nompumelelo Mkwanazi Prof Philippa C Matthews Prof Collins Iwuji Dr Motswedi Anderson Kathy Baisley Gregory Ording-Jespersen Mark Siedner Emily Wong Willem Hanekom Vukuzazi Field Team Sample Processing Unit Khanyi Msomi Theresa Smit Dickman Gareta Luthando Zuma Africa Health Research Institute Nesstar Publisher The Francis Crick Institute (core funding to the Hepatitis B Elimination Lab, ref CC2223), drawing on funding from Wellcome, MRC and Cancer Research UK University College London Biomedical Research Centre (BRC AHRI Wellcome Strategic Core award CC2223 227167/A/23/Z V1.0.0 Hepatitis B; HBV; vaccine-mediated immunity; HIV co-infection; seroprevalence; rural health; KwaZulu-Natal; South Africa; population surveillance; archived plasma samples; liver disease; public health equity. Hepatitis B virus; seroepidemiologic studies; coinfection; noncommunicable diseases; hepatitis, viral, human; HIV infections; public health surveillance; health status disparities; antiviral treatment; eligibility determination. ]]> South Africa Africa Health Research Institute (AHRI) demographic surveillance area in rural uMkhanyakude district, KwaZulu-Natal. Individual-level cross-sectional data. Each record represents a single plasma sample collected during the Vukuzazi programme (2018-2020) from a participant aged 15 years or older. Samples were retrospectively tested for HBV biomarkers. A subset of residents aged 15 years and older in the AHRI surveillance area who participated in the Vukuzazi health screening programme between May 2018 and March 2020. Survey Data, clinical data, biomarker data, administrative records data, spatial data A stratified random sample of 2,200 plasma samples was selected from the Vukuzazi biobank. Stratification was done by age group, sex and HIV status, and samples were randomly selected within each stratum. All serological and molecular testing followed validated laboratory protocols. Data were cleaned, linked and de-identified prior to analysis. Spatial analysis used GIS shapefiles from AHRI's surveillance area. Access to the data requires accurate completion of the online data access application form accessible on the AHRI Data repository(<https://data.ahri.org/>). Data users are required to abide by the data use conditions stipulated on the application for access to the data. Failure to do so may result in their data access privileges being revoked by the Data Custodian. In order to recognise the effort and intellectual contributions of AHRI investigators in producing and curating the data, users of AHRI data must acknowledge the source of the data and abide by the terms and conditions under which the data is accessed and must cite the dataset in publication using the citation provided as part of this documentation. All analytical datasets published on the AHRI Data Repository are assigned digital object identifier (DOIs) and the DOIs can be found on the Data Repository under Study Description tab - Access policy. AHRI data users are required to always cite the dataset using the relevant DOI. vk_evolve.NSDstat 2200 295 Nesstar 200801 IndividualId 2200 0 24 38776 18720.138 11239.035 IIntID 2200 0 129 246968 81753.316 54615.821 Sex 2200 0 1 Male 984 2 Female 1216 9 Unknown 0 2200 0 1926 2004 1984.855 16.663 HBV vaccine age epoch 2200 0 0 Born <1995 1203 1 1995–1999 562 2 2000–2005 435 Education level 2199 1 0 None 120 1 Primary 302 2 Secondary 1407 3 Tertiary 370 Sysmiss 1 Socioeconomic status 2127 73 1 Lowest 240 2 Low 601 3 Middle 517 4 High 374 5 Highest 395 Sysmiss 73 Alcohol intake 2200 0 0 Never drinker 1820 1 No drinking in last 12 months 48 2 Drinking in past 12 months 332 Smoking status 2200 0 1 Current smoker 221 2 Ex-smoker 20 3 Never smoker 1959 BMI category 2187 13 1 Underweight 139 2 Normal 1076 3 Overweight 493 4 Obese 479 Sysmiss 13 HIV status (ELISA) 2200 0 0 Negative 1100 1 Positive 1100 On ART (cascade) 1100 1100 0 No 302 1 Yes 798 Sysmiss 1100 Viral load <50 copies/mL (PLWH only) 1100 1100 0 Not suppressed 333 1 Suppressed 767 Sysmiss 1100 Hypertension 2195 5 0 No 1830 1 Yes 365 Sysmiss 5 Diabetes 2199 1 0 No 2063 1 Yes 136 Sysmiss 1 HBsAg_Interpretation 2200 0 HBsAb_Interpretation 2200 0 Anti_HBcII_Interpretation 2200 0 HBsAg_Result 2200 0 2200 0 0 6732.1 194.415 962.093 HBsAg positive (qualitative) 2200 0 0 No 1960 1 Yes 240 HBsAg S/CO > 10 (sensitivity definition) 2200 0 0 No 2071 1 Yes 129 Vaccine-mediated immunity (HBsAb+ / others -) 1312 888 0 No 1102 1 Yes 210 Sysmiss 888 Exposure & clearance (anti-HBc+ / HBsAg-) 1960 240 0 No 1312 1 Yes 648 Sysmiss 240 Susceptible (HBsAg-/anti-HBc-/anti-HBs-) 2200 0 0 No 1098 1 Yes 1102 2200 0 1.316 3.013 2.165 0.488 2200 0 1.849 63.441 16.315 12.031 Box_No 2200 0 870116 888227 878306.818 6647.337 Position_No 2200 0 Label_ID 2200 0 Text_ID 2200 0 Processing_barcode 2200 0 TrackCare_Barcode 2200 0 HBsAb_Result 2200 0 Anti_HBcII_Result 2200 0 Individual's Date of Birth 2200 1926-09-26 2004-11-08 Date of visit at the Vukuzazi mobile clinic 2200 2018-06-01 2020-03-13 Body Mass Index 2187 13 13.289 169 25.961 7.736 Date of Death 45 2018-11-07 2021-10-15 2200 0 Number clinic visits in past year (ClinicLink) 2200 0 0 47 2.419 3.396 Any clinic visits in past year (ClinicLink) 2200 0 0 No 1027 1 Yes 1173 9 Missing 0 Number hospitalisations in past year (HIS) 2200 0 Hospitalised in past year (HIS) 2200 0 0 No 2197 1 Yes 3 9 Missing 0 Ever consent to RDT in PIP (2017/2018) 2200 0 0 No 1466 1 Yes 734 9 Missing 0 SES score (component 1) 2127 73 -5.782 6.217 0.226 1.926 Straight-line distance to clinic named in previous variable 2193 7 0.09 9.48 2.843 1.801 Individual study outcome 2200 0 1 Did not attend mobile clinic 0 2 Lacked capacity 0 3 Disenrolled from the study 0 4 Enrolled into the study 2200 5 Non-contact 0 6 Premature-completion 0 7 Refused invitation card 0 8 No attempt made 0 9 Incomplete visit 0 10 Refused study enrolment 0 Date of visit at the homestead 2197 2018-05-24 2020-03-11 Age at recruitment 2197 3 15 92 33.491 16.661 Age category at recruitment 2197 3 1 <20 511 2 20-24 502 3 25-29 148 4 30-34 159 5 35-39 155 6 40-44 143 7 45-49 162 8 50-54 125 9 55-59 96 10 60-64 75 11 65-69 56 12 70+ 65 Sysmiss 3 Age at enrolment 2200 0 15 92 33.501 16.651 Age category at enrolment 2200 0 1 <20 509 2 20-24 506 3 25-29 147 4 30-34 160 5 35-39 155 6 40-44 144 7 45-49 162 8 50-54 124 9 55-59 97 10 60-64 74 11 65-69 57 12 70+ 65 PIP unique household Id 2199 1 16 43304 13216.223 11078.802 PIP unique bounded structure Id 2200 0 19 92378 10908.159 14248.392 This episode number (first=1, last=Episodes) 2194 6 1 71 23.95 8.316 Total number of episodes for individual 2194 6 1 71 23.95 8.316 Start date of episode (inclusive) 2194 2004-01-01 2018-12-21 End date of episode (inclusive) 2194 2004-02-03 2018-12-31 Whether individual is resident for duration of episode 2194 6 0 No 62 1 Yes 2132 Sysmiss 6 Education status of individual during this episode 2191 9 0 None 653 1 Grade 1 4 2 Grade 2 7 3 Grade 3 10 4 Grade 4 33 5 Grade 5 36 6 Grade 6 47 7 Grade 7 101 8 Grade 8 98 9 Grade 9 111 10 Grade 10 194 11 Grade 11 183 12 Grade 12 639 13 ? 0 14 Some tertiary 0 15 Tertiary qualification 75 Sysmiss 9 Marital status of the individual during this episode 1813 387 0 Unknown 0 1 Not married 544 2 Married 235 3 Widowed 102 4 Separated/divorced 4 5 Informal union 928 Sysmiss 387 Employment status of the individual during this episode 1773 427 0 Unknown 0 1 Yes 310 2 Part-time 72 3 No 1391 Sysmiss 427 Vukuzazi camp visit date 2200 2018-06-01 2020-03-13 Do you currently smoke any tobacco products, such as cigarettes, cigars or pipes 2200 0 0 No 0 1 Yes 221 2 1979 Do you currently smoke tobacco products daily? 221 1979 0 No 0 1 Yes 193 2 28 Sysmiss 1979 How old were you when you first started smoking? 147 2053 2 50 20.571 7.237 Years smoking daily (current smokers) 147 2053 0 66 17.306 13.03 Age started smoking unknown? 221 1979 0 No 0 1 Yes 55 2 166 Sysmiss 1979 Do you remember how long ago it was? 33 2167 1 40 17.03 11.326 Could you specify long ago it was? 55 2145 0 No 0 1 Yes 54 2 1 Sysmiss 2145 Do you smoke Other products? 221 1979 0 No 0 1 Yes 24 2 197 Sysmiss 1979 How old were you when you first started smoking (Age)? 13 2187 15 40 22.308 8.43 Started smoking in months 2 2198 Started smoking in weeks 2 2198 On average, how many of the following products do you smoke each day/week? 188 2012 On average, how many of the following products do you smoke each day/week? 189 2011 0 140 34.476 26.213 On average, how many of the following products do you smoke each day/week? 104 2096 On average, how many of the following products do you smoke each day/week? 103 2097 0 140 23.204 25.363 On average, how many of the following products do you smoke each day/week? 34 2166 On average, how many of the following products do you smoke each day/week? 35 2165 0 27 1.771 5.921 On average, how many Cigars, cheroots, cigarillos do you smoke each day? 32 2168 On average, how many of the following products do you smoke each day/week? 32 2168 0 88 3 15.575 On average, how many of the following products do you smoke each day/week? 34 2166 On average, how many of the following products do you smoke each day/week? 32 2168 0 50 2.656 10.624 On average, how many of the following products do you smoke each day/week? 24 2176 On average, how many of the following products do you smoke each day/week? 24 2176 3 125 29.042 29.698 During any visit to a doctor or other health worker in the past 12 months, were 2200 0 0 No 0 1 Yes 38 2 2162 In the past, did you ever smoke any tobacco products? 2032 168 0 No 0 1 Yes 29 2 2003 Sysmiss 168 In the past, did you ever smoke daily? 29 2171 0 No 0 1 Yes 24 2 5 Sysmiss 2171 Smoking status 2200 0 1 Current daily smoker 193 2 Current non-daily 28 3 Ex-smoker daily 17 4 Ex-smoker non-daily 3 5 Never smoked 1959 Smoking amount 188 2012 0 26 6.059 4.445 Smoking amount 188 2012 0 Never 6 1 Light 136 2 Moderate 41 3 Heavy 5 Sysmiss 2012 Quit smoking in months 2 2198 Quit smoking in weeks 2 2198 Quit smoking in years 8 2192 Do you remember how old you were when you last quit smoking? 22 2178 0 No 0 1 Yes 13 2 9 Sysmiss 2178 Have you ever consumed any alcohol such as beer, wine, spirits or [add other loc 2200 0 0 No 0 1 Yes 380 2 1820 Have you consumed any alcohol within the past 12 months? 380 1820 0 No 0 1 Yes 326 2 54 Sysmiss 1820 Have you stopped drinking due to health reasons, such as a negative impact on yo 356 1844 0 No 0 1 Yes 63 2 293 Sysmiss 1844 During the past 12 months, how frequently have you had at least one standard alc 380 1820 Have you consumed any alcohol within the past 30 days? 380 1820 0 No 0 1 Yes 130 2 250 Sysmiss 1820 During the past 30 days, on how many occasions did you have at least one standar 112 2088 0 30 4.643 5.758 During the past 30 days, when you drank alcohol, how many standard drinks on ave 124 2076 0 28 4.024 4.253 During the past 30 days, what was the largest number of standard drinks you had 123 2077 0 30 5.959 4.834 During each of the past 7 days, how many standard drinks did you have each day? 96 2104 0 28 4.385 4.655 During each of the past 7 days, how many standard drinks did you have each day? 41 2159 During each of the past 7 days, how many standard drinks did you have each day? 33 2167 During each of the past 7 days, how many standard drinks did you have each day? 40 2160 During each of the past 7 days, how many standard drinks did you have each day? 41 2159 During each of the past 7 days, how many standard drinks did you have each day? 96 2104 0 24 4.031 3.532 During each of the past 7 days, how many standard drinks did you have each day? 108 2092 0 24 5.37 4.018 During each of the past 7 days, how many standard drinks did you have each day? 77 2123 0 24 4.234 4.383 During the past 7 days, did you consume any homebrewed alcohol, any alcohol brou 130 2070 0 No 0 1 Yes 29 2 101 Sysmiss 2070 On average, how many standard drinks of the following did you consume during the 6 2194 On average, how many standard drinks of the following did you consume during the 28 2172 On average, how many standard drinks of the following did you consume during the 2 2198 On average, how many standard drinks of the following did you consume during the 1 2199 On average, how many standard drinks of the following did you consume during the 1 2199 Alcohol intake category 2200 0 0 Never drinker 1820 1 No drinking in last 12 months 48 2 Drank in last 12 months but not last 30 days 202 3 Drinking in last 30 days 130 Total drinks in 30 days 110 2090 0 336 21.4 41.759 Average drinks per week 110 2090 0 48 2.618 5.985 Alcohol use disorder risk (among drinkers in past 30 days 123 2077 1 High risk 70 2 Low risk 53 Sysmiss 2077 Heavy episodic drinking 130 2070 0 No 0 1 Yes 20 2 110 Sysmiss 2070 Age at the time of quiting smoking 13 2187 17 61 30.308 13.647 During any visit to a doctor or other health worker in the past 12 months, were 221 1979 0 No 0 1 Yes 16 2 161 3 44 Sysmiss 1979 Have you ever received a test result for HIV? 2200 0 0 No 0 1 Yes 1896 2 289 3 15 Have you ever had a positive HIV test result? 1896 304 0 No 0 1 Yes 838 2 1047 3 11 Sysmiss 304 Do you remember the exact date, or year of your first positive test result? 839 1361 1 Exact date 88 2 Year only 593 3 I don?t know 158 Sysmiss 1361 When was your first positive test result? 88 1900-01-01 2019-11-19 Year of First HIV Positive Result 594 1606 1983 2019 2012.929 5.306 Type of Last HIV Negative date 1029 1171 1 Exact date 207 2 Year only 737 3 I don?t know 85 Sysmiss 1171 When was your last negative test result? 0 Year Last HIV Negative Result 737 1463 1918 2020 2017.725 4.023 Have you ever been on ART? 784 1416 1 Yes 755 2 No 27 3 Refused to say 2 Sysmiss 1416 Do you remember the exact date, or year when you first started ART? 92 2108 1 Exact date 92 2 Year only 0 3 I don?t know 0 Sysmiss 2108 When did you first start ART? 92 1900-01-01 2019-11-19 Year Of ART Initiation 555 1645 1992 2019 2013.227 4.904 Are you currently receiving ART? 810 1390 0 No 0 1 Yes 799 2 11 Sysmiss 1390 Have you ever stopped/defaulted from ART treatment? (Defaulted explained as not 810 1390 0 No 0 1 Yes 21 2 784 3 5 Sysmiss 1390 21 2179 HIV Elisa Result 2200 0 1 Positive 1100 2 Negative 1100 3 Indeterminate 0 CD4 Lymphocytes Abs 1096 1104 6 2102 687.873 331.766 CD4 Lymphocytes % 1093 1107 2 58 28.908 9.955 CD8 Lymphocytes Abs 1097 1103 160 3815 1036.746 497.406 CD4/CD8 Ratio 1087 1113 0.02 3.58 0.783 0.474 11 .. CD8 Lymphocyte percent 1097 1103 13 84 43.252 12.487 HIV Viral Load Result 1104 1096 1 < 40 105 2 NOT DETECTED 662 43 1 44 2 47 1 55 1 56 1 58 3 59 1 60 1 61 1 65 2 66 1 69 1 70 1 71 1 72 3 73 1 75 1 76 1 78 1 81 1 82 1 83 1 118 1 122 1 126 1 135 1 139 1 140 1 147 1 156 1 157 1 158 1 162 1 166 1 168 1 178 1 209 1 212 1 215 1 260 1 272 1 303 1 341 1 368 1 384 1 402 1 416 1 421 1 433 1 479 1 490 2 495 1 509 1 519 1 550 1 556 1 566 1 576 1 598 1 675 1 679 1 721 1 744 1 757 1 777 2 785 1 803 1 804 1 809 1 814 1 871 1 885 1 891 1 900 1 916 1 977 1 987 1 1015 1 1037 1 1115 2 1123 1 1131 1 1138 1 1155 1 1157 1 1205 2 1221 1 1263 1 1277 1 1312 1 1389 1 1413 1 1520 1 1529 1 1637 1 1797 1 1874 1 1886 1 1924 1 1934 1 2019 1 2152 1 2220 1 2449 1 2605 1 2748 1 2778 1 2939 1 2986 1 2998 1 3227 1 3266 1 3353 1 3467 1 3636 1 3688 1 3793 1 3896 1 4032 1 4187 1 4230 1 4368 1 4498 1 4672 1 4707 1 4816 1 5057 1 5111 1 5113 1 5400 1 5479 1 5564 1 5936 1 5991 1 6233 1 6321 1 6407 1 6565 2 6599 1 6870 1 6881 1 6916 1 6974 1 7103 1 7134 1 7164 1 7785 1 8106 1 8128 1 8347.5 1 9046 1 9087 1 9246 1 9341 1 9405 1 9576 1 9600 1 9723 1 10399 1 10565 1 10708 1 10943 1 11191 1 11233 1 11385 1 11617 1 11783 1 12377 1 12453 1 12483 1 12630 1 12702 1 12801 1 12965 1 12974 1 13238 1 13252 1 13498 1 13585 1 13591 1 13787 1 13876 1 13926 1 14209 1 14243 1 14577 1 15379 1 15488 1 15849 1 17204 1 17401 1 17483 1 17555 1 17630 1 18033 1 18368 1 18775 1 19189 1 19826 1 20146 2 20297 1 21116 1 22320 1 23913 1 24237 1 24387 1 24470 1 24638 1 25494 1 25845 1 25912 1 26162 1 26503 1 27621 1 28052 1 28303 1 28564 1 28829 2 29530 1 29850 1 30413 1 30712.5 1 30913 1 31336 1 33489 1 33868 1 34472 1 35406 1 36272 1 36274 1 37154 1 37752 1 37886 1 38381 1 38533 1 40209 1 40389 1 40936 1 41212 1 41489 1 41687 1 41887 1 42334 2 42620 1 43106 1 43196 1 43604 1 45648 1 47457 1 49404 1 50048 1 50652 1 54054 1 54785 1 55919 1 56655 1 58253 1 58418 1 58448 1 58499 1 58884 1 59239 1 60184 1 66116 1 66323 1 70536 1 71375 1 72470 1 74444 1 74585 1 78146 1 79221 1 84395 1 85402 1 86729 1 87943 1 87960 1 88551 1 96680 1 96898 1 97400 1 107936 1 109956 1 113315 1 116132 1 116992 1 120963 1 120986 1 127784 1 128546 1 129542 1 146009 1 146992 1 149202 1 150993 1 156036 1 162977 1 167930 1 172431 1 173764 1 186047 1 190991 1 208126 1 224093 1 231496 1 236335 1 239538 1 261546 1 261854 1 269257 1 296026 1 314794 1 330210 1 374356 1 453783 1 467735 1 569412 1 586079 1 594140 1 643852 1 958358 1 4996628 1 6715552 1 10000001 .. 0 Sysmiss 1096 Viral load category 1104 1096 1 <400 818 2 >=400 286 Sysmiss 1096 Aware of HIV Status 2200 0 0 No 0 1 Yes 837 2 1363 HIV positive on ART and VL <400 1100 1100 0 No 0 1 Yes 814 2 286 Sysmiss 1100 VL<400 among those who report being on ART 798 1402 0 No 0 1 Yes 715 2 83 Sysmiss 1402 HIV positive on ART 1100 1100 0 No 0 1 Yes 897 2 203 Sysmiss 1100 HIV care cascade status 2200 0 0 Negative 1100 1 Positive and undiagnosed 264 2 Diagnosed not in care 38 3 In care, not controlled 83 4 Controlled 715 Are you currently on TB treatment? 2200 0 0 No 0 1 Yes 8 2 2192 If yes, have you received injections as part of this TB treatment? 8 2192 0 No 0 1 Yes 1 2 6 3 1 Sysmiss 2192 Have you been on TB treatment before? 2200 0 0 No 0 1 Yes 288 2 1807 3 105 If yes, how many times have you been on TB treatment? 288 1912 1 26 1.434 1.754 Age at TB treatment 130 2070 1 61 26.577 13.573 Do you remember the exact date, or year when you completed your last TB treatmen 278 1922 0 No 0 1 Yes 7 2 135 3 136 Sysmiss 1922 Please select the year of completion of last TB treatment 135 2065 1983 2018 2008.978 7.555 Do you remember how old you were when you had your FIRST diagnosis of TB? 0 2200 0 No 0 1 Yes 0 Sysmiss 2200 When did you start your current treatment for TB? 0 Duration of the symptom (weeks) 28 2172 1 48 6.714 12.584 Ever been on TB treattment weeks ago 18 2182 Ever been on TB treattment yearsago 80 2120 0 120 35.263 44.596 Date of completion of last TB treatment 0 Has anyone in your homestead (or residential plot), during your lifetime 2200 0 0 No 0 1 Yes 539 2 1485 3 176 Is anybody in your homestead (or residential plot) currently on TB treatment? 2200 0 0 No 0 1 Yes 52 2 1933 3 215 Do you currently have a cough? 2200 0 0 No 0 1 Yes 114 2 2086 If yes, how long have you had the cough 114 2086 1 58 3.851 7.647 If yes, do you cough up sputum? 114 2086 0 No 0 1 Yes 84 2 30 Sysmiss 2086 Do you have a fever? 2200 0 0 No 0 1 Yes 53 2 2147 If yes, how long have you had a fever? 53 2147 0 No 0 1 Yes 34 2 7 3 2 4 2 6 1 8 3 12 2 24 1 58 1 Sysmiss 2147 Do you have drenching night sweats? (Sweating at night that soaks your clothes o 2200 0 0 No 0 1 Yes 43 2 2157 How long have you had drenching night sweats? 43 2157 0 No 0 1 Yes 7 2 13 3 2 4 6 5 4 6 3 8 4 12 1 40 1 48 1 58 1 Sysmiss 2157 Have you lost weight in the last 6 months? 2200 0 0 No 0 1 Yes 32 2 2168 How much weight have you lost in the last 6 months? 31 2169 0 No 1 1 Yes 3 2 5 3 5 4 3 5 6 6 4 8 1 9 1 17 1 72 1 Sysmiss 2169 Do you have any other symptoms apart from those already mentioned? 2200 0 0 No 0 1 Yes 28 2 2172 Any of the four TB symptoms 2200 0 0 No 0 1 Yes 167 2 2033 Total TB symptoms 2200 0 0 No 0 1 Yes 5 2 2195 Chext X-Ray score 2086 114 14 100 31.697 15.763 Triage for sputum collection 2200 0 0 No 0 1 Yes 1240 2 960 Attempt to collect sputum 2200 0 0 No 0 1 Yes 1229 2 971 Sputum collected 1229 971 0 No 0 1 Yes 1101 2 128 Sysmiss 971 Spontaneous specimen obtained 1178 1022 0 No 0 1 Yes 1050 2 128 Sysmiss 1022 Reason for not obtaining spontaneous specimen 128 2072 1 Exempted 0 2 Unable_to_produce 118 3 Equipment_malfunctioning 0 4 Unsuccessful_bleed 0 5 Specimen_mislabelling 0 6 Refusal 10 7 Other 0 Sysmiss 2072 Induced Sputum Obtained 109 2091 0 No 0 1 Yes 5 2 104 Sysmiss 2091 Reason for not obtaining induced specimen 104 2096 1 Exempted 0 2 Unable_to_produce 103 3 Equipment_malfunctioning 0 4 Unsuccessful_bleed 0 5 Specimen_mislabelling 0 6 Refusal 1 7 Other 0 Sysmiss 2096 Spont TB SputumHome 51 2149 1 Yes 45 2 No 6 7 Not Applicable 0 Sysmiss 2149 Induced TBS putum Home 51 2149 1 Yes 1 2 No 5 7 Not Applicable 45 Sysmiss 2149 TB GeneXpert Test Result 1101 1099 1 MTB Not Detected 1086 2 MTB Detected Very Low 5 3 MTB Detected Low 5 4 MTB Detected Medium 0 5 MTB Detected High 0 6 MTB Detected 0 7 5 Sysmiss 1099 Liquid Culture Result(MGIT) 1091 1109 1 Negative MTB Not Isolated 993 2 Positive MTB Only(Mycobacterium Tuberculosis isolated) 12 3 Positive NTM Only 23 4 Culture Contaminated 49 5 Positive MTB And Contaminated(Mycobacterium Tuberculosis isolated) 0 6 Positive NTM And contaminated 14 7 Positive MTB And Positive NTM(Mycobacterium Tuberculosis isolated) 0 Sysmiss 1109 Rifampicin Resistance 1101 1099 0 Not detected 8 1 Detected 1 2 Indeterminate 6 7 Not applicable 1086 Sysmiss 1099 Time To Detection(days) 1091 1109 0 42 39.517 8.449 Time To Detection(hrs) 1091 1109 0 23 0.991 3.766 Solid Culture Incubation 0 2200 DST Isoniazid_0.2 12 2188 DST Isoniazid_1.0 12 2188 DST Rifampicin_1.0 12 2188 DST Ethambutol_7.5 12 2188 DST Streptomycin_2.0 12 2188 DST Ofloxacin_2.0 12 2188 DST Kanamycin_5.0 12 2188 Bacteriologically confirmed TB 1101 1099 0 No 0 1 Yes 17 2 1084 Sysmiss 1099 Bacteriologically confirmed TB or on treatmen 1102 1098 1 Positive 25 2 Negative 1077 3 Indeterminate 0 Sysmiss 1098 TB care cascade status 2076 124 0 No active TB 2051 1 Bacteriologically confirmed TB not on treatment 17 2 On TB treatment (with/without bact confirm) 8 Sysmiss 124 BP First Systolic 2199 1 65 221 117.64 18.733 BP First Diastolic 2199 1 33 815 74.379 20.474 BP Second Systolic 2197 3 61 222 116.517 17.87 BP Second Diastolic 2198 2 39 147 72.933 12.469 BP Third Systolic 2198 2 62 222 115.461 17.66 BP Third Diastolic 2198 2 38 140 72.422 12.658 BP Forth Systolic 19 2181 133 219 163.632 21.077 BP Forth Diastolic 0 2200 Mean diastolic BP (2nd & 3rd) 2199 1 38 143 72.455 11.695 Mean systolic BP (2nd & 3rd) 2199 1 69 222 115.722 17.185 Have you ever had your blood pressure measured by a doctor or other health worke 2200 0 0 No 0 1 Yes 1247 2 953 Have you ever been told by a doctor or other health worker that you have raised 1532 668 0 No 0 1 Yes 289 2 1243 Sysmiss 668 Have you been told in the past 12 months? 1002 1198 0 No 0 1 Yes 220 2 782 Sysmiss 1198 In the past 6 months, have you seen a doctor or other health care worker about y 1002 1198 0 No 0 1 Yes 206 2 796 Sysmiss 1198 In the past two weeks, have you taken any drugs (medication) for raised blood pr 1002 1198 0 No 0 1 Yes 199 2 803 Sysmiss 1198 Have you ever seen a traditional healer for raised blood pressure or hypertensio 2081 119 0 No 0 1 Yes 26 2 2055 Sysmiss 119 Are you currently taking any herbal or traditional remedy for your raised blood 875 1325 0 No 0 1 Yes 4 2 871 Sysmiss 1325 WHO STEPS BP group 2195 5 1 Normal 1197 2 Pre-hypertension 763 3 Hypertension stage 1 173 4 Hypertension stage 2 62 Sysmiss 5 BP controlled with medication 365 1835 0 No 0 1 Yes 49 2 316 Sysmiss 1835 Told had raised BP by health care worker in last 12 months 2200 0 0 No 0 1 Yes 264 2 1936 Seen health care worker in last 6m for raised BP 1533 667 0 No 0 1 Yes 223 2 1310 Sysmiss 667 Taken medication for raised BP in past 2 wks medication for raised BP in past 2 2200 0 0 No 0 1 Yes 199 2 2001 Taking herbal medication for raised BP 2068 132 0 No 0 1 Yes 4 2 2064 Sysmiss 132 Hypertension diagnosis (primary defn 2195 5 0 No 0 1 Yes 365 2 1830 Sysmiss 5 Hypertension care cascade status 2195 5 0 No HTN or pre-HTN 1830 1 HTN not in care 160 2 HTN in care but not controlled 75 3 HTN controlled 130 Sysmiss 5 Have you ever had your blood sugar measured by a doctor or other health worker? 2200 0 0 No 0 1 Yes 419 2 1781 Have you ever been told by a doctor or other health worker that you have raised 1092 1108 0 No 0 1 Yes 51 2 1041 Sysmiss 1108 Have you been told in the past 12 months? 872 1328 0 No 0 1 Yes 49 2 823 Sysmiss 1328 In the past 6 months, have you seen a doctor or other health care worker about y 871 1329 0 No 0 1 Yes 45 2 826 Sysmiss 1329 In the past two weeks, have you taken any drugs (medication) for diabetes prescr 871 1329 0 No 0 1 Yes 46 2 825 Sysmiss 1329 Are you currently taking insulin for diabetes prescribed by a doctor or other he 871 1329 0 No 0 1 Yes 9 2 862 Sysmiss 1329 Have you ever seen a traditional healer for diabetes or raised blood sugar? 2063 137 0 No 0 1 Yes 1 2 2062 Sysmiss 137 Are you currently taking any herbal or traditional remedy for your diabetes? 840 1360 0 No 0 1 Yes 2 2 838 Sysmiss 1360 Haemoglobin level 2199 1 1 Raised 124 2 Normal 2075 Sysmiss 1 Told had raised blood sugar by health care worker in last 12m 2200 0 0 No 0 1 Yes 60 2 2140 Diabetes diagnosis (primary definition) 2199 1 0 No 0 1 Yes 136 2 2063 Sysmiss 1 Diabetes controlled with medication 136 2064 0 No 0 1 Yes 12 2 124 Sysmiss 2064 Seen health care worker in last 6m for raised blood suga 2200 0 0 No 0 1 Yes 46 2 2154 Taken medication (non-insulin) for raised blood sugar in past 2 wks 2200 0 0 No 0 1 Yes 46 2 2154 Currently taking insulin for diabetes 2200 0 0 No 0 1 Yes 9 2 2191 Have you ever had your cholesterol (fat levels in your blood) measured by a doct 2200 0 0 No 0 1 Yes 23 2 2177 Have you ever been told by a doctor or other health worker that you have raised 848 1352 0 No 0 1 Yes 1 2 847 Sysmiss 1352 Have you been told in the past 12 months? 838 1362 0 No 0 1 Yes 4 2 834 Sysmiss 1362 In the past two weeks, have you taken any oral treatment (medication) for raised 838 1362 0 No 0 1 Yes 2 2 836 Sysmiss 1362 Diabetes care cascade status 2199 1 0 No DM or pre-DM only 2063 1 DM not in care 117 2 DM in care but not controlled 7 3 DM controlled 12 Sysmiss 1 Have you ever seen a traditional healer for raised cholesterol? 2059 141 0 No 0 1 Yes 3 2 2056 Sysmiss 141 Are you currently taking any herbal or traditional remedy for your raised choles 837 1363 0 No 0 1 Yes 0 2 837 Sysmiss 1363 Have you ever had a heart attack or chest pain from heart disease (angina)? 2200 0 0 No 0 1 Yes 16 2 2184 Are you currently taking aspirin regularly to prevent or treat heart disease? 2200 0 0 No 0 1 Yes 12 2 2188 Are you currently taking statins (Lovastatin/Simvastatin/Atorvastatin or any oth 2200 0 0 No 0 1 Yes 6 2 2194 Did your mother or father have a heart attack before the age of 60? 2200 0 0 No 0 1 Yes 16 2 1919 3 265 Have you ever had a stroke (cerebrovascular accident or incident)? 2200 0 0 No 0 1 Yes 40 2 2160 Are you currently taking aspirin regularly to prevent a stroke? 2200 0 0 No 0 1 Yes 13 2 2187 Are you currently taking statins (Lovastatin/Simvastatin/Atorvastatin or any oth 2200 0 0 No 0 1 Yes 5 2 2195 Did your mother or father have a stroke before the age of 60? 2200 0 0 No 0 1 Yes 37 2 1890 3 273 Have you been treated for cancer before? 2200 0 0 No 0 1 Yes 6 2 2194 Which cancer? 7 0 Blood Pressure referral follow up 92 2108 0 No 0 1 Yes 31 2 61 Sysmiss 2108 Diabetes referral follo 86 2114 0 No 0 1 Yes 50 2 35 3 1 Sysmiss 2114 Follow up Glucose Result 85 2115 4 25 8.565 4.666 Follow up Diabetes Diagnosis 85 2115 1 Diabetes 24 2 At risk of diabetes 52 3 Not Diabetestes 9 4 More information needed 0 Sysmiss 2115 Follow up Diabetes Clinic Date 0 2200 Follow up Diastolic BP 77 2123 62 112 84.961 12.158 UFollow up BP Diagnosis 77 2123 1 Normal blood pressure 41 2 Mildly raised blood pressure 16 3 Moderately raised blood pressure 16 4 High blood pressure 2 5 Severely raised blood pressure 2 Sysmiss 2123 HBA1c 2199 1 20 169 38.506 9.282 Hemoglobin percent 2199 1 4 17.6 5.675 0.851 101 .. RECODE of AgeAtEnrolmentCat (Age category at enrolment) 2200 0 1 <25 1015 2 25-44 606 3 45-64 457 4 65+ 122 RECODE of MaritalStatus (Marital status of the individual during this episode) 1813 387 1 Not married 544 2 Married 235 3 Previously married 106 4 Informal union 928 Sysmiss 387 RECODE of StopSmokingAdvice12mo (During any visit to a doctor or other health wo 221 1979 1 Yes 16 2 No 205 Sysmiss 1979 RECODE of Education (Education status of individual during this episode) 2191 9 1 None 653 2 Upto primary 238 3 Some secondary 586 4 Matric 639 5 Tertiary 75 Sysmiss 9 Is urban or rural 2200 0 1 Default 0 2 Peri-Urban 767 3 Rural 1316 4 Urban 117 99 Unknown 0 2195 0 2199 0 2200 2018-06-01 2020-03-13 2200 2018-11-07 2022-02-01 Design weight (prob of selection) 2200 0 1 39.68 8.158 7.568 2199 1 1 None 120 2 Primary 302 3 Secondary 1407 4 Tertiary 370 Sysmiss 1 2200 0 2200 0 2200 0 2200 0 2200 0 2200 0 2200 0 anti-HBs censoring flag 2200 0 -1 < (left-censored) 0 0 exact 2073 1 > (right-censored) 127 anti-HBs (mIU/mL), numeric (raw parsed) 2200 0 0 1000 110.139 260.889 anti-HBs ≥10 mIU/mL 2200 0 0 No 1384 1 Yes 816 2200 0 1 2200 1100.5 635.23