Pregnancy Registry Among Adolescent Girls and Young Women in Rural KwaZulu-Natal, South Africa: STI-Associated Maternal and Neonatal Outcomes, 2022-2025. AHRI.FD01-01.Fertility.Dataset.v1 Nompumelelo Mkwanazi Africa Health Research Institute Nesstar Publisher Pregnancy Registry Among Adolescent Girls and Young Women in Rural KwaZulu-Natal, South Africa: STI-Associated Maternal and Neonatal Outcomes, 2022-2025. AHRI.FD01-01.Fertility.Dataset.v1 Sweetness Dube Nompumelelo Mkwanazi Nqobile Ngoma Prof. Maryam Shahmanesh Thetha Nami Ngithethe Nawe Research Group Data Management Team KwaZulu-Natal Department of Health Africa Health Research Institute Nesstar Publisher v1.0.0 Pregnacy registry,Pregnacy surveillance,Sexually transmitted infections,HIV,Prep,ART,Adolecent girls and yung women,AGYW,Maternal outcomes,Pregnancy outcomes,Neonatal outcomes,Antenatal care,Chlamydia,Gonorhea,Syphilis,Hepatitis B,KwaZulu-Natal,South Africa,Thetha Nami Ngithethe NAWE,HDSS Pregnamcy,Pregnancy outcomes,Sexually transmitted Infections,Adolescent health,Adolescent and young Women,Young adult health,Maternal health,Neonatal health,Infant health,Antenatal care,Public health surveillance,Pre-exposure prophylaxis,Rural health South Africa This surveillance system was conducted in the uMkhanyakue District in the north of the KwaZulu-Natal Province, South Africa. Participants are residents of the AHRI HDSS setting, which comprises of approximately 40 community clusters that are served by 11 Department of Health Primary Health Clinics and one district hospital. Individual pregnant AGYW The surveillance universe comprises AGYW aged 15 to 30 years who were the Thetha Nami Ngithethe Nawe HIV Prevention and PrEP implementation trial embedded within the AHIR HDSS who became pregnant between 2022 and 2025. Eligible AGYW who consented to data linkage and had traceable Department of Health maternity case records were enrolled in this surveillance system. Retrospective longitudinal clinical registry and surveillance data A purposive sampling approach was used, including all ~300 eligible AGYW pregnancies from the Thetha Nami Ngithethe Nawe PrEP Implementation trial. Records meeting the inclusion criteria with traceable maternity case records were enrolled. Those with not traceable MCR and cannot be linked to AHRI data will be excluded. Accounting for potential missingness, we expected to analyse ~267 minimum records. A unique identifier generated from the HDSS used across all studies in this study frame was used to link the Thenami Ngithehte Nawe implementation database, laboratory STI testing database and the Department of Health MCR. RedCap validation rules were applied to control for outliers, out-of-range, and missing values in key variables. Quality assurance was conducted through the implementation process, the PI and liaising with the data collectors in the field for queries. Personal identifiers will be excluded from analysis and reporting. Access to the data requires accurate completion of the online data access application form accessible on the AHRI Data repository(<https://data.ahri.org/>). Data users are required to abide by the data use conditions stipulated on the application for access to the data. Failure to do so may result in their data access privileges being revoked by the Data Custodian. In order to recognise the effort and intellectual contributions of AHRI investigators in producing and curating the data, users of AHRI data must acknowledge the source of the data and abide by the terms and conditions under which the data is accessed and must cite the dataset in publication using the citation provided as part of this documentation. All analytical datasets published on the AHRI Data Repository are assigned digital object identifier (DOIs) and the DOIs can be found on the Data Repository under Study Description tab - Access policy. AHRI data users are required to always cite the dataset using the relevant DOI. FD01-01 Fertility Dataset v.1.NSDstat 60 55 Nesstar 200801 Record ID 60 0 Prep/Lapis Study ID 56 0 Facility Name 60 0 1 Hlabisa 39 2 KwaMsane 6 3 Mpukonyoni 0 4 Mtubatuba 0 5 Madwaleni 4 6 Ntondweni 0 7 Nkundusi 5 8 Hluhluwe 4 96 Other 2 MomConnect enrolled 59 1 0 No 38 1 Yes 11 99 Unknown 10 Sysmiss 1 Comorbidities 0 60 Method of Conception 52 8 1 Spontaneous 9 2 ART/IV 0 3 IUI 1 4 Unknown 42 Sysmiss 8 Planned Pregnancy 23 37 1 Yes 10 2 No 13 Sysmiss 37 Pregnancy complications 0 60 Dating method 44 16 1 LMP 28 2 Ultrasound 16 Sysmiss 16 Chorionicity 1 59 1 Yes 0 2 No 0 99 Unknown 1 Sysmiss 59 AFI/DVP - which is circled? 0 60 1 AFI 0 2 DVP 0 Sysmiss 60 Placental site 15 45 1 Anterior 6 2 Posterior 3 3 Fundal 5 4 Low-lying 1 Sysmiss 45 STI diagnosed/suspected at this visit? 46 14 1 Yes 6 2 No 31 99 Unknown 9 Sysmiss 14 How was the STI diagnosis made? (Clinical vs Etiological) 6 54 1 Clinical (syndromic) 5 2 Etiological (laboratory-confirmed) 1 3 Both clinical & etiological 0 99 Unknown 0 Sysmiss 54 What STI syndrome/type was recorded? (MCR-style) 6 54 1 Vaginal discharge syndrome (VDS) 3 2 Urethral discharge syndrome (UDS) 0 3 Genital ulcer syndrome (GUS) 0 4 Lower abdominal pain syndrome (LAPS/PID suspected) 1 5 Genital warts (HPV suspected) 0 96 Other 2 Sysmiss 54 STI treatment given today? 6 54 1 Yes 5 2 No 1 99 Unknown 0 Sysmiss 54 STI treatment type 5 55 1 Yes 3 2 No 1 3 Both 0 99 Unknown 1 Sysmiss 55 STI Treatment Regimen 9 51 1 VDS treatment: Ceftriaxone IM + Doxycycline + Metronidazole 1 2 GUS (genital ulcer) - HSV regimen: Acyclovir 0 3 GUS (genital ulcer) - Syphilis regimen: Benzathine Penicillin 1 4 Pelvic Inflammatory Disease/Lower Abdominal Pain Syndrome: Ceftriaxone IM + Doxycycline + Metronidazole 0 5 Urethral discharge syndrome: Ceftriaxone IM + Doxycycline 0 6 Trichomoniasis: Metronidazole 0 7 Bacterial vaginosis: Metronidazole 0 8 Candidiasis: Fluconazole 0 9 Gonorrhoea (lab confirmed): Ceftriaxone IM 0 10 Chlamydia (lab confirmed): Doxycycline 0 11 Mixed infection treatment: As per clinical combination 0 12 Partner treatment pack given 0 99 Other regimen / not documented 7 Sysmiss 51 Partner notification/treatment advised or given? 5 55 1 Yes 0 2 No 1 99 Unknown 4 Sysmiss 55 Follow-up for STI arranged? 5 55 1 Yes 2 2 No 1 99 Unknown 2 Sysmiss 55 Urinalysis done? 46 14 1 Yes 34 2 No 9 99 Unknown 3 Sysmiss 14 Urinalysis - Protein 34 26 0 Negative 26 1 Trace 1 2 + 4 3 ++ 3 4 +++ 0 Sysmiss 26 Urinalysis - Glucose 30 30 0 Negative 29 1 Trace 1 2 + 0 3 ++ 0 4 +++ 0 Sysmiss 30 Urinalysis - Nitrites 28 32 0 Negative 27 1 Positive 1 Sysmiss 32 Urinalysis - Ketones 28 32 0 Negative 26 1 Trace 0 2 + 0 3 ++ 1 4 +++ 1 Sysmiss 32 HIV status 58 2 0 Negative 49 1 Positive 7 99 Unknown 2 Sysmiss 2 ART started 7 53 0 No 0 1 Yes 5 99 Unknown 2 Sysmiss 53 PrEP initiated 53 7 0 No 33 1 Yes 12 99 Unknown 8 Sysmiss 7 PrEP modality 11 49 1 Oral pills 11 2 Long-acting injectable 0 3 Vaginal ring 0 Sysmiss 49 Syphilis test 53 7 0 Negative 43 1 Positive 7 99 Unknown 3 Sysmiss 7 Syphilis treated 7 53 0 No 0 1 Yes 7 99 Unknown 0 Sysmiss 53 Rh status 56 4 0 Negative 3 1 Positive 47 99 Unknown 6 Sysmiss 4 Anti-D given 3 57 0 No 3 1 Yes 0 99 Unknown 0 Sysmiss 57 Rupture of membranes 43 17 0 No 30 1 Yes 9 99 Unknown 4 Sysmiss 17 If yes, liquor character 9 51 1 Clear 9 2 Meconium-stained 0 3 Blood-stained 0 4 Offensive/foul smell 0 Sysmiss 51 Chorioamnionitis signs 33 27 1 Yes 0 2 No 33 Sysmiss 27 Chorioamnionitis signs 0 60 Other outcomes 0 60 Ectopic confirmed by ultrasound/surgery 0 60 0 No 0 1 Yes 0 99 Unknown 0 Sysmiss 60 Maternal outcome 55 5 1 Alive & discharged 55 2 Alive & inpatient 0 3 Transferred to higher care 0 4 Referred for follow-up 0 5 Lost to follow-up 0 6 Died 0 99 Unknown 0 Sysmiss 5 Reason for referral 0 60 1 Severe PPH 0 2 Hypertensive emergency 0 3 Suspected sepsis 0 4 Cardiac/respiratory compromise 0 5 Surgical indication 0 96 Other 0 Sysmiss 60 Infant sex 54 6 1 Male 31 2 Female 23 3 Ambiguous 0 Sysmiss 6 HIV exposed 56 4 1 Yes 6 2 No 50 Sysmiss 4 Birth PCR done? 55 5 1 Yes 2 2 No 47 99 Unknown 6 Sysmiss 5 Birth PCR result 2 58 0 Negative 0 1 Positive 0 99 Unknown 2 Sysmiss 58 Birth status 56 4 1 Live birth 56 2 Fresh stillbirth 0 3 Fresh stillbirth 0 Sysmiss 4 Infant delivery outcome 55 5 1 Discharged home 55 2 Died before discharge 0 3 Unknown 0 Sysmiss 5 Uterine contraction 44 16 0 No 2 1 Yes 36 99 Unknown 6 Sysmiss 16 Pad check 41 19 0 No 3 1 Yes 18 99 Unknown 20 Sysmiss 19 Urine passed 43 17 0 No 3 1 Yes 36 99 Unknown 4 Sysmiss 17 Catheter in situ 45 15 0 No 34 1 Yes 4 99 Unknown 7 Sysmiss 15 Uterus status 43 17 1 Contracted 33 2 Atonic 0 3 Ruptured 0 99 Unknown 10 Sysmiss 17 Perineum status 43 17 1 Intact 19 2 Tear 2 3 Tear 15 99 Unknown 7 Sysmiss 17 Perineum repaired 43 17 0 No 15 1 Yes 17 99 Unknown 11 Sysmiss 17 All swabs removed 43 17 0 No 4 1 Yes 13 99 Unknown 26 Sysmiss 17