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Thetha Nami ngithethe nawe (Let’s Talk)– STI Partner Treatment

South Africa, 2022 - 2025
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Reference ID
AHRI.PrEPImplementation.STI.Partner.Notification.2025.v1
Producer(s)
Prof Maryam Shahmanesh
Collections
Multilevel HIV Prevention
Metadata
Documentation in PDF DDI/XML JSON
Created on
Jan 29, 2025
Last modified
Jan 29, 2025
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  • Identification
  • Version
  • Scope
  • Coverage
  • Producers and sponsors
  • Sampling
  • Data collection
  • Data processing
  • Access policy
  • Metadata production

    • Identification

    Survey ID number
    AHRI.PrEPImplementation.STI.Partner.Notification.2025.v1
    Title
    Thetha Nami ngithethe nawe (Let’s Talk)– STI Partner Treatment
    Country
    Name Country code
    South Africa ZA
    Abstract
    Thetha Nami ngithethe nawe (Let's Talk): A stepped-wedge cluster randomised controlled trial of peer navigators' social mobilisation into community-based sexual health and HIV care (Including Pre-Exposure prophylaxis) to reduce sexual transmissible HIV among youth in rural KwaZulu-Natal, South Africa. The STI Partner Treatment component investigates the STI contact tracing, partner notification, and treatment among sexual reproductive health and HIV clinic mobile attendees in rural KwaZulu Natal.

    · Study Aim: To assess the effectiveness and feasibility of STI partner treatment strategies to curb the reinfection rates among sexual partners, enhance overall sexual reproductive health outcomes, and enhance the STI's clinical management.

    · Specific Objectives:
    1.To evaluate the effect of healthcare worker STI contact tracing, notification, and treatment
    2.To assess the feasibility of implementing healthcare worker partners' notification to augment the patient notification to curb STI transmission
    Kind of Data
    PrEP user's clinical data
    Unit of Analysis
    Sexual reproductive health and HIV-neutral service participants.

    Version

    Version Description
    v1.0.0

    Scope

    Topics
    Topic Vocabulary URI
    Adolescents; young adults; HIV infections/prevention & control; South Africa/epidemiology; sexual health; randomised controlled trials, PrEP; HIV prevention; clinical adherence; patient management. Africa Health Research Institute
    Keywords
    STI, partner notification, HIV prevention, clinical management

    Coverage

    Geographic Coverage
    Health and demographic surveillance site in the rural KwaZulu-Natal
    Universe
    About 26,000 15-30 AYAs from 40 geographical areas (clusters) of the uMkhanyakude District in the rural KwaZulu Natal are eligible to receive Thetha Nami ngithethe nawe" intervention. Of these, ~20% are at risk of HIV acquisition and would benefit from HIV and STI clinical management. The unit of randomisation is the administrative area supported by a pair of peer navigators: 40 administrative areas are randomised to receive the intervention, Thetha Nami ngithethe nawe: social mobilisation by peer navigators into mobile sexual and reproductive health clinics that provide tailored HIV prevention and care or the standard of care: access HIV care and prevention through primary care clinics.

    Participants must be able and willing to give written informed consent for trial participation, or assent and parental consent in the case of those aged 15-17. Adults 18+ years who are eligible for PrEP.

    Producers and sponsors

    Primary investigators
    Name Affiliation
    Prof Maryam Shahmanesh Africa Health Research Institute
    Producers
    Name
    Africa Health Research Institute
    Funding Agency/Sponsor
    Name Abbreviation Role
    Bill and Melinda Gates Foundation BMG Funder
    Other Identifications/Acknowledgments
    Name Affiliation Role
    Jaco Dreyer Africa Health Research Institute Data management, cleaning, and analysis
    Eva Ssozi Africa Health Research Institute Data management, cleaning, and analysis

    Sampling

    Sampling Procedure
    The primary outcome will be collected through three random representative population-based surveys:

    · n=2000 15-30-year-olds, 50 per cluster, at baseline,
    · n=3200 15-30-year-olds, 80 per cluster, at the end of period 1 (midline) and
    · n=3200 15-30-year-olds, 80 per cluster, at the end of period 2 (end-line).

    We use the AHRI health and demographic surveillance system (HDSS) as a sampling frame to randomly select three separate cross-sectional samples of:

    · n=3600 (90 per cluster) 15-30-year-olds stratified by gender at baseline. Based on previous studies in this setting, we anticipate that ~2800 will be contactable and eligible and that n=2000 (~50 per cluster) men and women aged 15-30, will be willing and able to provide consent to be included in the study.
    · n=6000 (150 per cluster) 15-30-year-olds stratified by gender at the midline (before the second step of scale-up) and end-line. Based on previous studies in this setting, we anticipate that 4300 will be contactable and eligible and that n=3200 (~80 per cluster) men and women aged 15-30, will be willing and able to provide consent to be included in the study

    Data collection

    Dates of Data Collection
    Start End
    2022-06-14 2025-01-20

    Data processing

    Data Editing
    The data collected and captured on REDCap was uploaded to a MySQL database server within AHRI's secure server cluster.

    Access policy

    Access conditions
    Access to the data requires accurate completion of the online data access application form accessible on the AHRI Data repository(<https://data.ahri.org/>). Data users are required to abide by the data use conditions stipulated on the application for access to the data. Failure to do so may result in their data access privileges being revoked by the Data Custodian. In order to recognise the effort and intellectual contributions of AHRI investigators in producing and curating the data, users of AHRI data must acknowledge the source of the data and abide by the terms and conditions under which the data is accessed and must cite the dataset in publication using the citation provided as part of this documentation. All analytical datasets published on the AHRI Data Repository are assigned digital object identifier (DOIs) and the DOIs can be found on the Data Repository under Study Description tab - Access policy. AHRI data users are required to always cite the dataset using the relevant DOI.
    Citation requirements
    Shahmanesh, Prof Maryam. (2025). Thetha Nami ngithethe nawe (Let’s Talk)– STI Partner Treatment [Data set]. Africa Health Research Institute.
    DOI:https://doi.org/10.23664/AHRI.PREPIMPLEMENTATION.STI.PARTNER.NOTIFICATION.2025

    Metadata production

    DDI Document ID
    AHRI.PrEPImplementation.STI.Partner.Notification.2025.v1
    Producers
    Name Abbreviation
    Africa Health Research Institute AHRI
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