HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa.
South Africa, 2022 - 2024
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AHRI.EVOLVE.PrEP
HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa.
| Name | Country code |
|---|---|
| South Africa | ZA |
Guidelines for Hepatitis B treatment released by the World Health Organization in 2024 include the potential for use of dual therapy, combining tenofovir with either emtricitabine or lamivudine. These fixed-dose combinations are also used for Pre-Exposure Prophylaxis (PrEP) in people at risk of Human Immunodeficiency Virus (HIV). We hypothesize that pre-existing HIV PrEP programmes can support access to HBV testing and treatment
At the Africa Health Research Institute (AHRI) in KwaZulu Natal, South Africa, we evaluated PrEP uptake and retention amongst adolescents and young adults aged 15-30 years. We reviewed HBV status, acceptance of PrEP and retention in follow-up between June 2022 - Sept 2024. We aimed to gather preliminary data to explore the prevalence of HBV infection among adolescents and young adults (AYA) engaging with sexual health screening and PrEP services, and to determine the uptake of PrEP for people testing HBV surface antigen (HBsAg)-positive.
We collected demographic data (gender, age and area of residence (rural/peri urban). We further collected data on HIV status, HBV status, and other sexually transmitted infections (STIs). We collected follow-up information on assessment for PrEP, PrEP uptake and return for PrEP refills.
Research question: What is the prevalence of HBV infection among adolescents and young adults (AYA) engaging with sexual health screening and PrEP services, and what is the uptake of PrEP among individuals testing positive for HBV surface antigen (HBsAg)?
Survey Data, Census/Enumeration data, aggregate data, clinical data, event/transaction data, program source code, machine-readable text, administrative records data, experimental data, psychological test, textual data,coded textual, coded documents, time budget diaries, observation data/ratings, process-produced data, etc. No description just a single phrase,e.g Genetic sequences
The study set out to study HBV testing uptake, results, PrEP acceptance and return for refills.
Version
V1.0.0
Scope
| Topic | Vocabulary | URI |
|---|---|---|
| : hepatitis B, South Africa, Pre-Exposure Prophylaxis, sexual health | Africa Health Research Institute | www.ahri.org |
Coverage
Data were obtained from KwaZulu-Natal, in the uMkhanyakude district, South Africa.
The study explored programmes providing HIV PrEP for tackling HBV infection in adults and young adults (AYA) aged 15-30 years. We collected demographic data (gender, age and area of residence (rural/peri urban). We further collected data on HIV status, HBV status, sexually transmitted infections (STIs). Data on PrEP uptake and retention was collected.
Producers and sponsors
| Name | Affiliation |
|---|---|
| Maryam, Shahmanesh | Africa Health Research Institute / University College London/ University College London Hospital |
| Gloria, Sukali | Africa Health Research Institute/ University College London/ The Francis Crick Institute |
| Philippa,Matthews | University College London/ The Francis Crick Institute/ University College London Hospital |
| Collins, Iwuji | Africa Health Research Institute/ University of Sussex |
| Jacob,Busang | Africa Health Research Institute |
| Carina ,Herbst | Africa Health Research Institute |
| Nonhlanhla,Okesola | Africa Health Research Institute |
| Jaco,Dreyer | Africa Health Research Institute |
| Name |
|---|
| Africa Health Research Institute |
| Name | Abbreviation | Role |
|---|---|---|
| Bill and Melinda Gates foundation | BMGF | Funder |
| US National Institute of Health | NIH | Funder |
| Africa Health Research Institute (core funding from the Wellcome Trust strategic core award) | Wellcome | Sponsor |
| National Institute of Health research | NIHR | Funder |
| Francis Crick Institute | N/A | Funder |
| AHRI-UCL PhD fellowship | N/A | Funder |
| Name | Affiliation | Role |
|---|---|---|
| Thetha nami | Africa Health Research Institute | Study participant recruitments |
| LAPIS study teams | Africa Health Research Institute | Study participant recruitments |
Sampling
Data were collected and recorded by 'Thetha nami ngithethe nawe' ('Talk to me and I'll talk to you' in IsiZulu), which is a stepped-wedge cluster-randomised controlled trial to investigate the effectiveness, implementation and cost effectiveness of peer-led social mobilisation into decentralised HIV and sexual reproductive health (SRH) services, and by LAPIS, which is embedded within the second period of the Thetha nami step wedge trial. LAPIS is a cluster-randomised controlled trial of effectiveness and implementation offering a choice of injectable PrEP, continuous oral daily PrEP, dapivirine vaginal rings, or packs of oral post exposure antiviral prophylaxis for HIV prevention, compared with the offer of oral PrEP alone.
Data collection
| Start | End |
|---|---|
| 2022-06-06 | 2024-08-30 |
Data processing
Data were analysed at the Africa Health Research Institute (AHRI) as part of a collaboration with the Francis Crick Institute, London, linked to the EVOLVE-HBV study.
Data Access
Access to the data requires accurate completion of the online data access application form accessible on the AHRI Data repository(https://data.ahri.org/). Data users are required to abide by the data use conditions stipulated on the application for access to the data. Failure to do so may result in their data access privileges being revoked by the Data Custodian. In order to recognise the effort and intellectual contributions of AHRI investigators in producing and curating the data, users of AHRI data must acknowledge the source of the data and abide by the terms and conditions under which the data is accessed and must cite the dataset in publication using the citation provided as part of this documentation. All analytical datasets published on the AHRI Data Repository are assigned digital object identifier (DOIs) and the DOIs can be found on the Data Repository under Study Description tab - Access policy. AHRI data users are required to always cite the dataset using the relevant DOI.
This work is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
Shahmanesh, M., Sukali, G., Matthews, P., Iwuji, C., Busang, J., Herbst, C., Okesola, N., & Dreyer, J. (2025). HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa [Data set]. Africa Health Research Institute.
DOI:https://doi.org/10.23664/AHRI.EVOLVE.PREP
Metadata production
DDI.EVOLVE.PrEP
| Name | Abbreviation |
|---|---|
| Africa Health Research Institute | AHRI |