Abstract
The Sesikhona study is the first of its kind study using smartphone-based GPS technology to record ultra-high resolution mobility patterns of over 200 young adults aged 20-30 years in rural KwaZulu Natal. The study seeks to identify distinct movement typologies within this highly mobile, HIV hyper-endemic population and to quantify travel in and out of known high-risk locations, with the long-term goal of developing a location-intelligent smartphone intervention that delivers real-time, precision messaging to individuals at heighten risk of HIV acquisition, transmission or treatment interruption. Conducted in three phases between 2021 and 2025, the study used the Avicenna Research Platform to collect GPS and survey data. Between 2023 and 2025, consenting individuals self-completed monthly mobile health surveys to assess the use of technology including quality of the smartphone, change of cell phone number, phone sharing, network coverage and data and airtime spend, as well as experience with and willingness to use mobile health. 22754, 25867, 22753, 22755, 22757, 22756