The direct and indirect effects of HIV/ AIDS on the Health and wellbeing of older people study (WOPS)- Wave 3
During 2009-2010, the previously Africa Centre for Population Health, now Africa Health Research Institute (AHRI) was awarded funding from the National Institutes of Ageing (NIA) through the World Health Organization (WHO) to conduct a cross sectional survey (Wave 1) entitled 'The direct and indirect effects of HIV/ AIDS on the health and wellbeing of older people'. The participants were 400 people aged 50 years and over. The Wave 1 full study report was published in collaboration with the WHO.
During 2012-2013, further funding was obtained from the NIA through WHO and Wave 2 of the survey was conducted with 422 older people aged 50 years and over. Efforts were made to trace all participants from Wave 1 who were still alive during Wave 2. The Wave 2 full study report was published in collaboration with the WHO. In addition, a number of papers have been published from the Wave 1 and 2 data. We have obtained funding to conduct Wave 3 (2015) and Wave 4 (2018) from NIA through WHO.
This dataset is from wave 3 of the study. All participants seen in Wave 1 and Wave 2 of the study who are still alive were traced and invited to participate. We administered a questionnaire and conducted the biological sampling and clinical performance testing. The Wave 3 questionnaire and other tests are similar to those used in Wave 1 and Wave 2. The questionnaire and the data collection process was an electronic capture system.
Older adults who have died were replaced and a further 403 participants were added to achieve a sample size within the HIV positive and HIV negative groups of people aged 50 years and older.
The goal of the study is to contribute to the evidence base to guide the development and implementation of health programmes to meet older people's needs, especially those who have offspring infected or dead due to HIV/AIDS but also older people who are infected with HIV themselves. The basic research questions of the study is: (a) What are the effects of HIV/AIDS and its treatment on the health status (physical and mental) of older people? (b) What are the effects of HIV/AIDS on the income and social situation of older people? (c) What are the family tasks and responsibilities of older people who have offspring infected or dead due to HIV/AIDS and how do they differ from those of older people who do not have an offspring infected or dead due to HIV/AIDS? (d) In addition, it will be possible to assess risk factors for mortality among older people.
Participants will be asked for consent to participate in the various sections of the study and for storage and future epi-genetic studies from the saliva sample.
The overall goal of the study is to describe longitudinally the survival, health and wellbeing of older people who are directly and indirectly affected by HIV/AIDS, with special attention to the effects of the introduction of ART.
1. To describe the effects of HIV (with and without ART) on the (physical and mental) health and wellbeing of older people.
2. To determine the effects of HIV in older people especially older women on their social situation, with special focus on care giving.
3. Describe some of the biomarkers associated with chronic inflammation and immune function in the ageing process.
4. To document the risk factors for mortality among older people affected and infected with HIV.
Kind of Data
Survey data; process-produced data from the laboratory
Unit of Analysis
Questionnaire, biological sampling and clinical performance units.
Older people, HIV, ageing, frailty, South Africa
Africa Health Research Institute
Health and aging, HIV in older people
Africa Health Research Institute
Demographic surveillance area of the Africa Health Research Institute.
A description of the population covered by the data in the file; the group of persons or other elements that are the object of the study and to which the study results refer. Age, nationality, and residence commonly help to delineate a given universe, but any of a number of factors may be involved, such as age limits, sex, marital status, race, ethnic group, etc. The universe may consist of elements other than persons, such as specimen, sample or isolate. In general, it should be possible to tell from the description of the universe whether a given individual or element (hypothetical or real) is a member of the population under study. Also known as universe of interest, population of interest, and target population.
The demographic surveillance area of the Somkhele site of the Africa Health Research Institute (AHRI) (previously known as the Africa Centre for Health and Population Studies) was the study setting.
Study population and recruitment of participants:
In WOPS Wave 3, we surveyed all participants who were seen during Wave I and Wave 2 who were still living. For those who have died, we obtained information on mortality from the next of kin or relatives. Additional participants were recruited randomly until an overall sample size of 600 was achieved. We tried to ensure that we attempt to recruit replacements who are both infected and affected by HIV to retain the mix of different types of experience of HIV within the cohort. This resulted in 803 HIV positive and negative participants eventually being enrolled into the cohort.
At initial recruitment, WOPS (Wave 1 and 2), study participants were equally divided into five study groups
The five study groups include:
1. Older people who were HIV-infected but not yet on ART
2. Older people who were HIV-infected and on ART
3. Older people who had a child living with HIV
4. Older people who had a child who died of AIDS-related illness
5. Older people who were not HIV infected, had no known adult HIV infection in the family and had not lost an adult child due to HIV.
This balance of experience of living with/without HIV/AIDS and/or caring for someone with HIV/AIDS will be maintained for Wave 3, with replacements for people who have died or moved away for each group.
Producers and sponsors
Professor Janet Seely
Dr Anita Edwards
Africa Health Research Institute
KwaZulu-Natal Research Innovation Sequencing Platform
Cleaned, aligned and help analyse the sequence data.
Dates of Data Collection
Assays were performed on Dry Blood Spots (DBS) in the Durban based laboratory of AHRI.
Assay results were presented in the standard LIMS file format.
1. The representative of the Receiving Organization agrees to comply with the following conditions:
2. Access to the restricted data will be limited to the Lead Researcher and other members of the research team listed in this request.
3. Copies of the restricted data or any data created on the basis of the original data will not be copied or made available to anyone other than those mentioned in this Data Access Agreement, unless formally authorized by the Data Archive.
4. The data will only be processed for the stated statistical and research purpose. They will be used for solely for reporting of aggregated information, and not for investigation of specific individuals or organizations. Data will not in any way be used for any administrative, proprietary or law enforcement purposes.
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If there are any changes to the project specification, security arrangements, personnel or organization detailed in this application form, it is the responsibility of the Lead Researcher to seek the agreement of the Data Archive to these changes. Where there is a change to the employer organization of the Lead Researcher this will involve a new application being made and termination of the original project.
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